The Strain Engineering Company
That Only Gets Paid When You Succeed
High-capacity strain engineering delivering 10–15x expression increases and >80% COGS reduction, validated at commercial scale. Zero payment until you confirm the results in your own system.
Built for Commercial Scale
High-capacity genetic integration with expression levels far exceeding standard single-copy systems, validated in production environments.
10–15x Expression Increase
High-capacity genetic integration enables expression levels far exceeding standard single-copy systems. Validated in Pichia pastoris and E. coli at commercial scale.
12-Week Development
Systematic design approach delivers validated production strains in 12 weeks. Accelerate commercialization while maintaining performance standards.
No Regulatory Approvals
Endogenous genetic elements eliminate regulatory requirements with confirmed genetic stability across multiple production campaigns.
Development Process
Target Evaluation
Protein sequence analysis and production host assessment
Vector Design
High-capacity integration vectors with optimized genetic elements
Strain Validation
Performance confirmation at pilot and commercial scale
Production Transfer
Tech transfer with manufacturing process optimization
15x Expression at Over 100 kL Scale
Validated with global biomanufacturing partner in commercial bioreactors.
- Confirmed across multiple production campaigns
- Stable performance with no genetic drift
Proven at Commercial Scale
Experienced team with a track record in industrial strain engineering
Lior Zelcbuch, PhD
20+ years in synthetic biology and industrial fermentation. PhD, Weizmann Institute. Knows what breaks when you move from bench to commercial-scale production.
LinkedIn
Ben Adivi
Closed multi-year deals with contract manufacturers, CROs, and global biotech companies. Built TiterUp around a model where incentives align with the client.
LinkedInReady to Get Started?
Schedule a 30-minute call to discuss your protein target and production goals.
Book an Intro CallOr email ben@titerup.com
High-Capacity Strain Engineering
Our proprietary platform enables unprecedented levels of genetic integration by overcoming the traditional 7–8 copy bottleneck.
Discuss Your ProjectBeyond Standard Genetic Integration
Traditional genetic engineering approaches face a bottleneck at 7–8 gene copies, severely limiting expression potential. Our platform achieves stable, high-copy integration through a sophisticated multi-component vector architecture.
The result: dramatically higher titers, lower production costs, and faster time to market, all validated at commercial scale.
Core Technology Components
Multi-Component Vectors
Engineered vector architecture for high-copy integration with maintained cellular fitness and genetic stability.
Metabolic Optimization
Co-optimization of expression cassettes and metabolic pathways for maximum productivity at scale.
Endogenous Elements
Host-specific genetic components eliminate regulatory requirements while ensuring robust expression.
Validated Technical Advantages
Performance confirmed across multiple hosts and production scales
Multi-Component Vector Architecture
Sophisticated design enables stable high-copy integration while maintaining cellular fitness
Metabolic Co-Optimization
Expression cassettes and metabolic pathways engineered together for maximum productivity
Broad Host Compatibility
Platform validated across prokaryotic and eukaryotic hosts including E. coli and Pichia pastoris
Host-Specific Elements
Endogenous components eliminate regulatory requirements while maintaining stable, high-level expression
TiterUp vs the Alternatives
| Metric | Traditional Labs | Large Competitors | TiterUp |
|---|---|---|---|
| Gene copies per cell | 1–5 | 8–12 | 100+ |
| Output increase | 1.2–1.5x | 2–3x | 3–15x |
| Time to validated strain | 18–24 months | 12–18 months | <6 months |
| Production scale | Lab only | R&D varies | Proven at 100kL+ |
| Revenue model | Hourly/project fees | Fees + equity | Pay on results only |
See Our Technology in Action
Review detailed case studies and validated results from commercial-scale production
Performance Data from Industrial Scale
Fermentation data from production runs with global biomanufacturing partners, across multiple campaigns.
Pichia pastoris: Industrial-Scale Validation
Detailed performance data from industrial-scale fermentation validated with global biomanufacturing partner.
Performance Metrics
- Global biomanufacturing partner collaboration
- Multiple production campaign verification
- Benchmarked against standard single-copy systems
Methodology: All measurements conducted under identical fermentation conditions with standardized protocols to ensure direct comparability.
E. coli: Multi-Enzyme Pathway Optimization
Through systematic design iteration, we achieved progressive improvements in metabolite production, culminating in a 15.5-fold increase over baseline, 2x the highest titer previously reported in scientific literature.
Note: Design 5 represents 2x the highest titer previously reported in scientific literature. Multi-enzyme design variants showing progressive optimization of metabolite production.
Ready to Discuss Your Project?
Talk through your protein target and what realistic improvements look like for your system.
Get in TouchPay Only for Results
Zero payment until we deliver validated titer improvements in your production system
How It Works
Define Success Metrics
We establish clear, quantitative production targets specific to your protein and fermentation system before any work begins.
Deliver Engineered Strains
Our platform develops high-capacity strains and validates performance in controlled fermentation conditions.
Validate in Your System
Payment occurs only after you confirm the agreed titer improvements in your own production environment.
Why Success-Based Pricing
No Development Risk
Traditional strain engineering projects charge for effort regardless of outcome. We only get paid when we hit your production targets.
Proven Track Record
Demonstrated success in industrial fermentation environments gives us confidence in delivering results worth paying for.
Fast Turnaround
Efficient development process delivers production improvements without extended consulting engagements.
Complete Transparency
Success metrics established upfront with clear validation protocols. No ambiguity about what triggers payment.
Ready to Discuss Your Project?
Contact us to define success metrics for your protein target and structure a results-based engagement
Get in TouchThe Team
Two founders with direct experience taking a precision fermentation product from lab to over 100 kL commercial scale.
Lior Zelcbuch, PhD
Chief Technology Officer & Co-founder
View LinkedIn ProfileBefore co-founding TiterUp, Lior spent a decade running R&D programs that had to actually work at scale, not in a lab but in commercial bioreactors. He holds a PhD in Synthetic Biology from the Weizmann Institute and has over 1,400 scientific citations, but his real edge is knowing what breaks when you move from bench to 100,000-liter production. That combination of deep molecular biology and hard-won process experience is what TiterUp is built on.
His career spans engineered yeast systems, phage biology, and large-scale bioprocessing. Prior to TiterUp he served as VP of R&D at a precision fermentation company, leading strain development from early concept through industrial-scale production, and before that as Head of Research at BiomX, where his phage engineering work advanced multiple therapies now in Phase 2 clinical trials.
Ben Adivi
Chief Executive Officer & Co-founder
View LinkedIn ProfileBen's background is in closing deals in industrial biotech, multi-year contracts with contract manufacturers, CROs, and global biotech companies. He knows what these buyers care about and how they evaluate risk, which is part of why TiterUp's business model is structured the way it is.
He has negotiated and closed multi-million dollar agreements across the precision fermentation sector, working with partners ranging from early-stage producers to established global manufacturers. He co-founded TiterUp to build a firm where the incentives actually align with the client.
Start a Conversation
Talk through your production targets and see if there is a fit
Book a Call or Send a Note
Book an Intro Call
Schedule a 30-minute conversation to discuss your protein production goals and learn how our strain engineering platform can improve yields in your production system.
Schedule Your CallPrefer email?
ben@titerup.comCommon Questions
Straight answers to what most people ask before starting a conversation with us.
Each party retains its own IP. TiterUp keeps the underlying platform and vector technology. The client keeps their protein sequence, production data, and any improvements to their existing process. Neither party gains rights to the other's background IP.
The client pays nothing. Success metrics and validation criteria are defined upfront in the contract. If we don't hit them, there is no payment obligation.
Engagements are non-exclusive by default. Exclusivity within a defined product category or market is available and can be structured as part of the commercial terms.
Yeast, fungi, and bacteria. Most of our work and the deepest validation is in yeast, particularly Pichia pastoris. We also have strong experience in E. coli.
No full strain sequence is required to get started. We need the target protein sequence. All information shared is covered under a mutual NDA before any technical discussion begins.
From target evaluation to a validated shipment of first strains is typically 12 weeks. The timeline depends on the complexity of the protein and your fermentation system, and we'll scope that before any work begins.